Xoddo is a relatively new design-your-own-character type of site. You can use their handy design tool (it uses Flash) to add eyes, hair, shoes, etc. to your character...or you can upload your own artwork. Or do both!
I created my own character and will be reviewing it once the standard Xoddo plush is produced (these are made-to-order). The above photo is not my design. I went white trash superhero furry with my design.
The company features Plush Xoddos in three different sizes (from $20 to $68), as well as Wall Decal Sets and Throw Blankets.